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1.
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles.
Hamilton, Alex G; Swingle, Kelsey L; Mitchell, Michael J.
PLoS Biol ; 21(4): e3002105, 2023 04.
Article in English | MEDLINE | ID: covidwho-2323474

ABSTRACT

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.


Subject(s)
Nanoparticles , Nucleic Acids , Liposomes
2.
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines.
Swingle, Kelsey L; Hamilton, Alex G; Mitchell, Michael J.
Trends Mol Med ; 27(6): 616-617, 2021 06.
Article in English | MEDLINE | ID: covidwho-1598490

Subject(s)
COVID-19/therapy , Cystic Fibrosis/therapy , Drug Delivery Systems , Liposomes/chemistry , Nanoparticles/chemistry , Polyneuropathies/therapy , RNA, Messenger/administration & dosage , Vaccines/administration & dosage , COVID-19/genetics , COVID-19/virology , Cystic Fibrosis/genetics , Humans , Polyneuropathies/genetics , RNA, Messenger/chemistry , SARS-CoV-2/physiology , Vaccines/chemistry
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